Sedating antidepressants sleep
Some heroin users may take them either to supplement their drug or to substitute for it.Stimulant users may take sedatives to calm excessive jitteriness.Lorazepam is one such pharmacological agent that can cause anterograde amnesia.Intensive care unit patients who receive higher doses over longer periods, typically via IV drip, are more likely to experience such side effects.Malcolm Lader at the Institute of Psychiatry in London estimates the incidence of these adverse reactions at about 5%, even in short-term use of the drugs.The paradoxical reactions may consist of depression, with or without suicidal tendencies, phobias, aggressiveness, violent behavior and symptoms sometimes misdiagnosed as psychosis.The use of these medications can further impede cognitive function for people with dementia, who are also more sensitive to side effects of medications.Sedatives can sometimes leave the patient with long-term or short-term amnesia.
Although sedatives do not relieve pain in themselves, they can be a useful adjunct to analgesics in preparing patients for surgery, and are commonly given to patients before they are anaesthetized, or before other highly uncomfortable and invasive procedures like cardiac catheterization, colonoscopy or MRI.
The long-term use of benzodiazepines may have a similar effect on the brain as alcohol, and are also implicated in depression, anxiety, posttraumatic stress disorder (PTSD), mania, psychosis, sleep disorders, sexual dysfunction, delirium, and neurocognitive disorders (including benzodiazepine-induced persisting dementia which persists even after the medications are stopped).
Additionally, benzodiazepines can indirectly cause or worsen other psychiatric symptoms (e.g., mood, anxiety, psychosis, irritability) by worsening sleep (i.e., benzodiazepine-induced sleep disorder).
They are central nervous depressants and interact with brain activity causing its deceleration.
Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA), which are brain chemicals performing communication between brain cells.
Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death.