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The MI ranged from 20 to 65 (mean = 34.98 and SD = 5.34).
The lightest mean pigmentation was observed in Brazil (32.04) and the darkest mean pigmentation in Mexico (36.32) (Fig. We have previously reported genome-wide association analyses of categorical hair color in the CANDELA sample.
Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated with skin pigmentation in Africans.
We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, probably after their split from Europeans.
To this end, here we report a genome-wide association study (GWAS) of pigmentation in over 6000 Latin Americans, most with high Native American ancestry.
It is well established that Native Americans are closely related to East Asians, the initial settlement of the New World starting some 15,000 years ago, through migration from Eastern Siberia into North America.
Overall, our findings highlight the complex genetic architecture of pigmentation phenotypes in Latin Americans, and support the view that, in modern humans, lighter skin pigmentation has evolved independently at least twice in Eurasia, possibly as an adaptation to geographic variation in solar radiation exposure..
To keep this resource 100% free for users, we receive advertising compensation from the sites listed on this page.Furthermore, we detected an association signal for skin pigmentation within the MFSD12 gene, which is strongest for an Y182H amino-acid variant that is common only in East Asians and Native Americans.Other variants of MFSD12 have recently been shown to impact on skin pigmentation in Africans.And if you find yourself living a more hectic schedule, online dating lifts the constraints of having to trek down to a social setting to interact with local singles.Remember, that in prehistoric times men would not live all that long, so the ones that did were more likely to pass on their genes.
Alternatively, it has been proposed that variation in human pigmentation could have been affected by sexual selection, or a form of frequency-dependent selection, as appears to be the case in many other animals.